"Local factions have taken control of more areas in Daraa province, including Daraa city... They now control more than 90 percent of the province, as regime forces successively pulled out," the Syrian Observatory for Human Rights said.
In Daraa province, only the Sanamayn area is still in government hands, Rami Abdel Rahman, who heads the British-based monitor with a network of sources in Syria, told AFP.
Earlier Friday, local factions seized the Nassib-Jaber border crossing with Jordan, the Observatory said, with Jordan closing its side of the crossing, Interior Minister Mazen al-Faraya said.
Daraa province was the cradle of the 2011 uprising against Syrian President Bashar al-Assad's rule, but it returned to government control in 2018 under a ceasefire deal brokered by Assad ally Russia. It was a rebel bastion at the height of the civil war in the early 2010s.
Former rebels there who accepted the 2018 deal were able to keep their light weapons.
Daraa province has been plagued by unrest in recent years, with frequent attacks, armed clashes and assassinations, some claimed by the Islamic State group.