An international team of researchers including Svante Paabo and Qiaomei Fu of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, sequenced nuclear and mitochondrial DNA that had been extracted from the leg of an early modern human from Tianyuan Cave near Beijing, China.

Analyses of this individual's DNA showed that the Tianyuan human shared a common origin with the ancestors of many present-day Asians and Native Americans. In addition, the researchers found that the proportion of Neanderthal and Denisovan-DNA in this early modern human is not higher than in people living in this region nowadays.

Humans with morphology similar to present-day humans appear in the fossil record across Eurasia between 40,000 and 50,000 years ago. The genetic relationships between these early modern humans and present-day human populations had not yet been established.

Qiaomei Fu, Matthias Meyer and colleagues of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, extracted nuclear and mitochondrial DNA from a 40,000 year old leg bone found in 2003 at the Tianyuan Cave site located outside Beijing.

For their study the researchers were using new techniques that can identify ancient genetic material from an archaeological find even when large quantities of DNA from soil bacteria are present.

The researchers then reconstructed a genetic profile of the leg's owner. "This individual lived during an important evolutionary transition when early modern humans, who shared certain features with earlier forms such as Neanderthals, were replacing Neanderthals and Denisovans, who later became extinct", says Svante Paabo of the Max Planck Institute for Evolutionary Anthropology, who led the study.

The genetic profile reveals that this early modern human was related to the ancestors of many present-day Asians and Native Americans but had already diverged genetically from the ancestors of present-day Europeans.

In addition, the Tianyuan individual did not carry a larger proportion of Neanderthal or Denisovan DNA than present-day people in the region. "More analyses of additional early modern humans across Eurasia will further refine our understanding of when and how modern humans spread across Europe and Asia", says Svante Paabo.

Qiaomei Fu, Matthias Meyer, Xing Gao, Udo Stenzel, Hernan A. Burbano, Janet Kelso, Svante Paabo DNA analysis of an early modern human from Tianyuan Cave, China PNAS, Online Early Edition, January 21, 2013