The UN's World Intellectual Property Organization said Shenzhen-Hong Kong-Guangzhou remained in second place, while Beijing overtook Seoul to grab third place.
WIPO, the UN agency dealing with patenting and innovation, said that China, for the second consecutive year, led with the most clusters in the top 100, at 26 (up two), followed by the United States with 20 clusters.
WIPO's Global Innovation Index publishes an annual top 100 science and technology clusters ranking, using patent filing and scientific publishing data to identify local concentrations of world-leading science and technology activity.
The top two clusters combined account for almost one of every five patent applications filed globally, driven by Japan's Mitsubishi Electric and Chinese telecom giant Huawei.
While there was little change in the top 10, further down the rankings, clusters in middle-income economies experienced the strongest growth, WIPO said.
China's Hefei and Zhengzhou led the way with 23 percent and 19 percent growth in science and technology output, followed by Cairo (11 percent), Chennai (eight percent) and Istanbul (eight percent).
"Most North American and European clusters fell in the ranking," WIPO said.
Sao Paulo, in 73rd place, was the only top 100 cluster in Latin America, while Cairo in 95th spot was the only one in Africa, with the Egyptian capital entering the rankings for the first time.
Kuala Lumpur, ranked 93rd, also made its debut in the top 100 clusters.
"Science and technology clusters serve as the foundation of robust national innovation ecosystems," WIPO chief Daren Tang said.
"It is encouraging to see these clusters thriving not just in the mature hubs of industrialised nations, but also in the emerging innovation hotspots of selected developing economies."
After China and the United States, Germany had the most clusters with eight, led by Munich in 22nd place.
South Korea and India, led by 56th-placed Bengaluru, had four each, while France, Britain, Japan and Canada have three clusters each in top 100.
WIPO said the clusters with the most intensive science and technology activity in proportion to population size were Britain's Cambridge, followed by San Jose-San Francisco in the United States and Eindhoven in the Netherlands.
In an additional focus on Africa that looked beyond the world's top 100, the continent's top five clusters were Cairo, Johannesburg, Cape Town, Tunis and Alexandria, with many African clusters driven by science activity rather than patent filings.
- Top 15 -
The top 15 science and technology clusters by size in 2024:
1: Tokyo-Yokohama (Japan)
2: Shenzhen-Hong Kong-Guangzhou (China)
3: Beijing (China)
4: Seoul (South Korea)
5: Shanghai-Suzhou (China)
6: San Jose-San Francisco (United States)
7: Osaka-Kobe-Kyoto (Japan)
8: Boston-Cambridge, (United States)
9: Nanjing (China)
10: San Diego (United States)
11: New York City (United States)
12: Paris (France)
13: Wuhan (China)
14: Hangzhou (China)
15: Nagoya (Japan)
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