"Hundreds" of missiles and barrel bombs were unleashed before dawn by both Syrian and Russian aircraft, after talks on rebel surrenders broke down on Wednesday, the Syrian Observatory for Human Rights said.

The intensity of the bombardment allowed government forces to seize control of a security checkpoint on the Jordanian border for the first time in more than three years, the Britain-based monitoring group said.

Observatory director Rami Abdel Rahman said the bombardment was an "attempt to make the rebels back down after they refused to subject themselves to the Russian terms for a ceasefire."

Some rebel groups have agreed to negotiated surrenders but on Wednesday evening the remainder walked out of talks with a Russian delegation saying they would not agree to hand over their heavy weapons.

An AFP correspondent on the edge of the rebel-held south of the city of Daraa, the divided provincial capital, said the bombing of rebel neighbourhoods was the most intense since the launch of the Russian-backed offensive on July 19.

Damascus has unleashed similar bombardment of rebel-held towns elsewhere in Syria in the past that have delivered negotiated surrenders which allowed it to retake swathes of territory.