"I shall take advantage of this opportunity to send a message to Assad: throw the Iranians out," a defence ministry statement quoted Lieberman as saying during a visit to the Israeli-occupied Golan Heights.

"They are not helping you," he said. "They only do harm and their presence brings only damage and problems."

Israel claims it struck dozens of Iranian targets inside Syria early on Thursday in response to a salvo of rockets fired by Iranian forces into the occupied Golan Heights.

Israeli Prime Minister Benjamin Netanyahu said Iran had "crossed a red line" and that Israel's bombardment against targets in Syria "was a consequence".

Israel carried out the raids after it said Iran's Al-Quds force fired 20 rockets, either Fajr or Grad type, at its forces in the Golan.

It has long warned it will not accept Iran entrenching itself militarily in neighbouring Syria, where the Islamic Republic backs Assad's regime in the country's seven-year civil war.

It has been blamed for a series of recent strikes inside Syria that have killed Iranians, though it has not acknowledged those raids.

The Jewish state says it has conducted dozens of operations in Syria to stop what it says are advanced arms deliveries to Iran-backed Hezbollah, another key foe of Israel.

Israel had been preparing itself for weeks for possible Iranian retaliation.