"The Israeli enemy launched an air attack from the direction of Lebanon, targeting a central site and a residential building in Baniyas city in the coastal region, killing a girl and wounding 10 civilians," a ministry statement said.

The Syrian Observatory for Human Rights war monitor said the girl was killed and 20 civilians wounded in the Israeli strike, after earlier reporting she died when an Israeli missile and Syrian air defence missile exploded and then fell on the coast.

The Britain-based Observatory also said the Israeli strike on central Syria killed three Syrian fighters working with Lebanon's Hezbollah group.

"Three Syrian fighters working with the Lebanese Hezbollah group were killed in an Israeli strike targeting a military site... in the eastern countryside of Homs," said the monitor which has a wide network of sources inside Syria.

Earlier on Wednesday, state media had said air defences intercepted Israeli "targets" over central Syria, and the Observatory reported an Israeli attack on a military site.

"Syrian air defence intercepts enemy targets in the skies of the city of Homs," the official SANA news agency reported.

The Observatory said the Israeli strikes targeted "at least one military site... in the eastern countryside of Homs, causing plumes of smoke to rise".

The monitor said the area also housed members of Iran-backed groups including Lebanon's powerful Hezbollah movement.

On Saturday, an Israeli drone strike in central Syria, near the border with Lebanon, killed two Hezbollah fighters, the Observatory had said.

Israel rarely comments on individual strikes in Syria but has repeatedly said it will not allow its arch-enemy Iran to expand its presence there.

Israel has carried out hundreds of strikes in Syria since the outbreak of the civil war in its northern neighbour, mainly targeting army positions and Iran-backed fighters including from Hezbollah.

The strikes have increased since Israel's war with Hamas in the Gaza Strip began on October 7, when the Iran-backed Palestinian militant group launched an unprecedented attack against Israel.

Syria's war has killed more than half a million people and displaced millions more since it erupted in 2011 after Damascus cracked down on anti-government protests.