"We call for these strikes to be fully investigated," the foreign ministry said, highlighting a strike on Tuesday on a school near the southern city of Khan Yunis.

"It is unacceptable that schools, especially those housing civilians displaced by the fighting, should be targeted," the ministry statement said.

"We call on Israel to do its utmost to protect civilians in the conduct of military operations and to fully respect international humanitarian law, in particular the principles of proportionality and distinction."

Israel is carrying out a large-scale military operation in Gaza to root out Hamas militants in the wake of a cross-border assault on October 7 last year.

The Israeli assault has killed at least 38,295 people, mostly civilians, according to health authorities in the Hamas-run territory.

Hundreds of thousands have been displaced within the densely populated territory.

In the past four days, deadly strikes have hit four schools used as shelters, sparking international outrage.