His comments on his Truth Social platform came after Israel pounded Iran in a series of air raids on Friday, striking 100 targets.

The operation killed senior figures -- among them the armed forces chief and top nuclear scientists -- and Iran has called Israel's wave of strikes a "declaration of war."

On Friday morning, Trump said: "I gave Iran chance after chance to make a deal."

He added that Israel -- which Trump has closely aligned with since his return to the White House -- has a lot of weapons thanks to the United States and "they know how to use it."

"There has already been great death and destruction, but there is still time to make this slaughter, with the next already planned attacks being even more brutal, come to an end," Trump said on his Truth Social platform.

"Iran must make a deal, before there is nothing left... JUST DO IT, BEFORE IT IS TOO LATE," he said.

Trump earlier told Fox News he had been made aware of the Israeli strikes before they happened, and stressed that Tehran "cannot have a nuclear bomb," the US broadcaster said.

He also said that "we are hoping to get back to the negotiating table," according to Fox News.

During Trump's first term, he pulled the United States out of a landmark agreement to relieve sanctions on Iran in return for curbs on its nuclear program.

Fox News also reported that Trump's administration reached out to at least one key Middle Eastern ally to acknowledge that the strike was going to happen, but said the United States was not involved.

"Trump noted the US is ready to defend itself and Israel if Iran retaliates," Fox News said.

Secretary of State Marco Rubio said earlier Thursday that the United States was "not involved in strikes against Iran and our top priority is protecting American forces in the region."

"Let me be clear: Iran should not target US interests or personnel."

Trump was attending a National Security Council meeting Friday at the White House.