"The time has come for the Iranian people to unite around its flag and its historic legacy, by standing up for your freedom from the evil and oppressive regime," Netanyahu said in a video statement after Israel struck over 200 military and nuclear sites in the Islamic republic.

"We are in the midst of one of the greatest military operations in history, Operation Rising Lion," he added.

"As we achieve our objective, we are also clearing the path for you to achieve your freedom," he said, referring to Israeli strikes that hit targets across Iran, including nuclear sites, killing several top military commanders and nuclear scientists.

"The regime does not know what hit them, or what will hit them. It has never been weaker," Netanyahu said in his video published shortly after a salvo of Iranian missiles reached Israel.

"Our fight is against the murderous Islamic regime that oppresses and impoverishes you," he said, adding: "This is your opportunity to stand up and let your voices be heard."

Netanyahu also promised that "more is on the way", having said earlier that Israel's attack on Iran would "continue for as many days as it takes".

Iran called the attack "a declaration of war" and threatened to retaliate by opening "the gates of hell" on Israel.

It first sent about 100 drones towards Israel, many of which were intercepted before reaching the country.

The drones were followed by dozens of missiles, some of which caused physical damage in Israeli cities, and injured at least seven people, according to first responders.