"MDA medics and paramedics are providing medical treatment and are taking a 16-year-old boy to the hospital in serious condition, with shrapnel in his upper body, and a 54-year-old man in moderate condition with a shrapnel injury to his lower limbs," the MDA said in a statement, without specifying their location.

A military official said that "approximately 20 missiles were launched towards Israel" in this last Iranian salvo.

Sirens sounded in Jerusalem and across Israel on Friday afternoon after the army said missiles had been fired from Iran.

Around 20 minutes later, the army released a statement saying people were allowed to leave protected spaces.

Earlier Friday, sirens rang out in parts of the country following an Iranian missile launch.

Police later said they were operating "at the site of a projectile impact" in the southern Israeli city of Beersheba, alongside emergency response teams and bomb disposal experts.

AFP footage from the impact scene showed security forces inspecting a crater near residential buildings, where the wreckage of charred cars lay below the mangled metal of destroyed balconies.

Israel, saying Iran was on the verge of developing nuclear weapons, launched a massive wave of strikes last week, triggering an immediate retaliation from Tehran.

The death toll in Israel from Iranian missile strikes since June 13 is 25 people, according to authorities.

Iran said on Sunday that Israeli strikes had killed at least 224 people, including military commanders, nuclear scientists and civilians.