Here are the latest developments:

- Iran says more than 400 killed -

Israeli strikes on Iran have killed more than 400 people since they began last week, the Islamic republic's health ministry said in an updated toll.

"As of this morning, Israeli attacks have claimed the lives of over 400 defenceless Iranians and left 3,056 others wounded by missiles and drones," health ministry spokesman Hossein Kermanpour said in a post on X Saturday.

A US-based NGO, the Human Rights Activists News Agency, said on Friday that based on its sources and media reports, at least 657 people have been killed in Iran, including 263 civilians.

- Strikes in southwest Iran, northern Israel -

Several "powerful explosions" were heard in the afternoon in southwestern Iran's Ahvaz, the daily Shargh reported, as Israel's military said it was conducting strikes on "military infrastructure" in the area.

Ahvaz is the capital of Khuzestan province, which lies on the Iraqi border and is Iran's main oil-producing region.

AFP journalists also reported hearing explosions in north and central Tehran on Saturday evening.

Earlier, Israeli rescue services said an Iranian "drone strike hit a two-storey residential building in northern Israel" following a wave of attacks reported by the military.

Iran's President Masoud Pezeshkian warned his country's "response to the continued aggression of the Zionist regime will be more devastating" during a phone call with French President Emmanuel Macron, according to the official IRNA news agency.

- Israel says killed 3 Iranian commanders -

Israel's military said it had killed a top Iranian official in charge of military coordination with the Palestinian militant group Hamas, as well as two other Iranian commanders overnight.

Israeli "fighter jets struck and eliminated in the area of Qom the commander of the Palestine Corps of the Quds Force, and the key coordinator between the Iranian regime and the Hamas terrorist organisation, Saeed Izadi", the military said in a statement.

The Quds Force is the foreign operations arm of Iran's powerful Islamic Revolutionary Guard Corps.

A military official also told reporters that Israel had killed two other Iranian commanders overnight, Behnam Shahriyari and Aminpour Judaki.

Iran's Fars news agency reported Saturday evening that "five army officers were killed and nine others were wounded" in an Israeli strike in the western city of Sumar.

- Israel hits Isfahan nuclear site -

Israel targeted "two centrifuge production sites" at Iran's Isfahan nuclear facility overnight in a second wave of strikes on the location, "advancing the damage to the facility", a military official said.

The repeated raids have "dealt a severe blow to Iran's centrifuge production capabilities", the official added.

The UN's nuclear watchdog, the Vienna-based International Atomic Energy Agency, confirmed a centrifuge manufacturing workshop at the site had been hit in the strike.

Pezeshkian, during his call with his French counterpart, said his country had long been willing "to provide guarantees and build confidence in its peaceful nuclear activities".

"However, we do not agree to reduce nuclear activities to zero under any circumstances," he added.

- Huthi threat -

Yemen's Tehran-backed Huthi rebels said they would restart their attacks on US-linked vessels and warships in the Red Sea if Washington got "involved in... aggression against Iran with the Israeli enemy", the group's military spokesman Yahya Saree said.

After the start of the war in Gaza in late 2023, the Yemeni rebels began firing at military and civilian vessels in the Red Sea that they accused of ties to Israel and the United States, saying they were acting in solidarity with the Palestinians.

The group agreed to a ceasefire with the United States last month after an intense bombing campaign by Washington, but it has not stopped firing missiles at Israel.

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