"At 00:15 (2115 GMT Monday) the Israeli enemy carried out an air strike... and the attack resulted in the death of two civilians," state news agency SANA said, quoting a military source.

The strikes came from the direction of "the occupied Syrian Golan, targeting some points in the vicinity of Damascus and the southern region", it said, adding that air defence intercepted "most of them".

During more than a decade of civil war in Syria, Israel has launched hundreds of air strikes on Syrian territory, primarily targeting Iran-backed forces and Lebanese Hezbollah fighters as well as Syrian army positions.

SANA had earlier reported "an explosion heard in the vicinity of Damascus".

The Syrian Observatory for Human Rights war monitor said that "Israeli missiles targeted the area of the Damascus International Airport, an Iranian complex near the Sayyida Zeinab area," and another location in al-Kiswah.

On Sunday, two Iran-affiliated fighters were killed in an Israeli air strike on targets in Syria, according to the British-based monitor with a wide network of sources inside the country, with SANA reporting five Syrian soldiers wounded.

Israel struck early Sunday near the western Syrian city of Homs, after striking the Syrian capital Thursday and early Friday.

The Syrian war broke out in 2011 with the brutal repression of peaceful anti-government protests, and escalated into a deadly armed conflict that pulled in foreign powers and global jihadists.

More than half a million people have been killed and around half of Syria's pre-war population has been forced from their homes.