The strong quake struck 82 kilometres (51 miles) northeast of Crete's capital Heraklion at 0319 GMT at a depth of 68 kilometres (42 miles), the USGS said.
AFP journalists said it was felt as far away as Athens and Egypt.
State television ERT said many residents in the Cretan regions of Rethymno and Lasithi were woken by the quake just after 6:00 am and quickly exited their homes as a precaution.
Local media showed supermarket items strewn on floors, and reported minor rockslides on rural roads.
The tremor "occurred at a great depth and there is no particular reason for residents to worry," Athanassios Ganas, general director of Research at the Geodynamics Institute of the National Observatory of Athens, told ERT.
State news agency ANA said fire department units in Crete had been placed on general alert, with vehicles patrolling to assess the situation.
The mayor of Heraklion, Alexis Kalokerinos, told ERT that there were no particular problems in the city and that closing schools would not be necessary.
The quake struck just over a week after a 6.1-magnitude tremor hit near the island of Kasos east of Crete, and was felt in the outlying area.
The region, popular with tourists, has been hit with multiple tremors in recent months, prompting schools in Santorini and neighbouring islands to temporarily close.
Thousands of earthquakes, mainly of low magnitude, have been recorded since January between the islands of Santorini, Amorgos, Ios and Anafi in the Cyclades group southeast of the Greek mainland.
They have not caused casualties or significant damage.
Located where the African and Anatolian tectonic plates converge, the Aegean Sea is often hit by quakes.
But the region had not experienced a phenomenon of such magnitude since records began in 1964, experts say.
6.4-magnitude quake hits off Papua New Guinea coast: USGS
Sydney (AFP) May 20, 2025 -
A 6.4-magnitude earthquake struck on Tuesday off the northern coast of Papua New Guinea, the US Geological Survey said.
The quake struck at a depth of 10 kilometres (6.2 miles) around 81 kilometres from the town of Angoram, it said, revising an earlier depth and distance as well as an earlier magnitude of 6.6.
The US tsunami warning agency said there was "no tsunami threat from this earthquake".
Earthquakes are common in Papua New Guinea, which sits on top of the seismic "Ring of Fire" -- an arc of intense tectonic activity that stretches through Southeast Asia and across the Pacific basin.
Although they seldom cause widespread damage in sparsely populated areas, they can trigger destructive landslides.
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